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Observe Carefully (1)pentobarbital will lessen the level or outcome of fentanyl transdermal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Intently. Coadministration of fentanyl with CYP3A4 inducers may lead to your minimize in fentanyl plasma concentrations, insufficient efficacy or, probably, enhancement of a wit